Buy Pregabalin Online Uk
What is Pregabalin?
Buy Pregabalin Online UK – Pregabalin 300 mg is referred to as an anti-epileptic drug, but it is versatile in the sense that it can be used for treating seizures of varying intensity as well as nerve damage that is a result or symptom of conditions such as diabetes or shingles. It is used for partial seizures as well as epilepsy and generalised anxiety disorder. It is sold at pharmacies and online, usually under the brand name Lyrica.
Buy Pregabalin Online Uk
There are other, less popular, trade names under which you can buy pregabalin online. At Sleeping Pills UK customers can buy Pregabalin without the need for a doctor’s prescription.
What is Pregabalin Used For?
Buy Pregabalin Online UK – A pregabalin tablet is generally used as an anti-convulsant. The primary function of this medication is to treat seizures, as approved by the food and Drug administration (FDA). However, there are other reasons to buy pregabalin.
FDA-approved uses include the treatment or management of:
- Neuropathic pain from diabetes, spinal cord injury and shingles (an infection caused by the herpes zoster virus)
Off-label uses include:
- Lower back pain
- Alcohol withdrawal syndrome
The success of pregabalin in seizures
Active epilepsy is presented with a prevalence of 0.5 to 1% of adults. Approximately 70% of people diagnosed with epileptic seizures are able to control the effects using a single anti-epileptic medication. Others may require additional medicines as add-on treatments for the management of this disorder. According to Mollamohammadi et al. (2014), pregabalin was effective in treating refractory seizures in adults and children. The patients were monitored and analyzed one month and four months after beginning treatment. Some showed up to a 50% reduction in seizure activity.
The success of pregabalin as anti-anxiety medication
The World Federation of Biological Psychiatry recommends using a pregablin dose as a first-line treatment for generalized anxiety disorder (GAD). Lyrica is approved in Europe for the treatment of this anxiety disorder.
Randomized controlled studies conducted by Baldwin and other researchers (2013) indicated the use of pregabalin for both acute treatment and the prevention of relapse of GAD. This study concluded that the anxiolytic medication was efficacious in reducing the symptoms of this disorder physically and physiologically. In addition, there was also a visible reduction in the co-existing symptoms of depression.
The success of pregabalin in neuralgia
A pregabalin tablet can be considered a first-line treatment of post-herpetic neuralgia, central neuropathic pain and diabetic neuropathy. This recommendation comes from the European Federation of Neurological Societies. Pregabalin is considered equal in efficacy to tricyclic depressants. In addition, pregabalin was the first medication to receive FDA approval for diabetic neuropathy and post-herpetic neuralgia treatment.
The major advantage of this analgesic is its reliability, high tolerance and ease of administration in patients with neuropathic pain (Verma et al., 2014). Re-clinical and clinical studies have proved the effectiveness of pregabalin in neuralgia.
The success of pregabalin for fibromyalgia
This disorder involves intense musculoskeletal pain and can be accompanied by fatigue, sleep disturbances and changes in moods. Anyone can develop fibromyalgia but the typical trend observed is that this disorder is prevalent in women.
Boomershine (2010) conducted a study investigating the use of pregabalin in fibromyalgia patients. The study revealed that this treatment was useful in improving the sleeping patterns, reduced pain and increasing the quality of life in these patients. The improvements of fatigue and anxiety related to this disorder were also shown to be statistically significant.
The success of pregabalin for low back pain
Low back pain ranks within the top 10 conditions responsible for the highest number of disability-adjusted lifestyles around the globe. It is one of the most frequent complaints of patients. Okur et al. (2018) researched the use of pregabalin for low back pain. They suggested that this type of chronic pain has two components, namely, nociceptive and neuropathic. For the neuropathic component, it is advised to buy pregabalin as this study indicated the efficacy of the analgesic is significant.
How Does Pregabalin Work?
Brain cells operate at a specific rate for normal body functioning. Seizures affect these operations by forcing the brain cells to work much quicker than they generally do. It is not well established how pregabalin works to stop seizure activity but there some theories to the mechanisms of action. It is thought that the basic mode of action is for the anti-epileptic medication to prevent the brain cells to function as rapidly as seizures affect them to.
Pregabalin is classified as a gabapentinoid. Gabapentinoids are a class of medicines which are derived from the inhibitory neurotransmitter GABA (gamma-aminobutyric acid). They block the subunits which contain voltage-dependent calcium channels. Even though this class of medicine is a structural analogue of GABA, it is not known to influence the uptake of GABA or interact with GABAA and GABAB receptors.
The most likely target of pregabalin action is the inhibition of the calcium channels. This contributes to a lowered release of excitatory neurotransmitters which consequently inhibits synaptic transmission. Other mechanisms of action for the analgesic properties of this medication can include:
- Excitatory amino acid transportation
- Modulation of potassium channel conductance